BONN, Germany (Reuters) -U.S. Treasury Secretary Janet Yellen said on Wednesday that COVID-19 lockdowns in China appear to be impeding the flow of goods and hampering global supply chains and a broader slowdown in growth in the world's No. 2 economy could have global spillover effects that warrant close attention.

PHILADELPHIA (Reuters) -Pennsylvania's hotly contested U.S. Senate Republican primary between TV personality Dr. Mehmet Oz and former hedge fund executive David McCormick was still undecided on Wednesday, after a technical error delayed the counting of thousands of ballots.

U.S. stock indexes opened lower on Wednesday as a rally in growth shares faded and downbeat results from retailer Target Corp added to worries over surging inflation.

The government of Panama and energy companies, including SGP BioEnergy, plan to develop a major, advanced biorefinery to increase supply of lower-carbon aviation fuel, the companies said Wednesday.

Pipeline firm Tallgrass Energy on Wednesday said it will convert a natural gas pipeline into carbon dioxide service, and ship CO2 from an Archer-Daniels-Midland Co corn-processing plant in Nebraska to a permanent underground storage hub in Wyoming.

(Reuters) -Wall Street's main indexes were set for a lower open on Wednesday following a sharp rally in megacap growth stocks in the previous session that fizzled out on fears of aggressive monetary policy tightening and slowing economic growth.